Nutrient stress is a target for new antibiotics

January 27, 2023

Authors: Carfrae LA, Brown ED

Reference: Trends Microbiol. 2023 January 27; doi: 10.1016/j.tim.2023.01.002

CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

January 6, 2023

Authors: Alcock BP, Huynh W … Bhando B, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM … Brown ED … McArthur AG.

Reference: Nucleic Acids Res. 2023 January 6; doi: 10.1093/nar/gkac920

An Omniphobic Spray Coating Created from Hierarchical Structures Prevents the Contamination of High-Touch Surfaces with Pathogens

January 1, 2023

Authors: Abu Jarad N, Rachwalski K, Bayat F, Khan S, Shakeri A, MacLachlan R, Villegas M, Brown ED, Soleymani L, Didar TF

Reference: Small 2023 January 1; doi: 10.1002/smll.202205761

Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

September 15, 2022

Authors: Yaeger LN, French S, Brown ED, Côté JP, Burrows LL

Reference: bioRxiv 2022 September 15; doi: 10.1101/2022.09.14.507886

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria

September 13, 2022

Authors: Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED.

Reference: ACS Infect. Dis. 2022 September 13; doi: 10.1021/acsinfecdis.2c00357

A genetic platform to investigate the functions of bacterial drug efflux pumps

September 5, 2022

Authors:Teelucksingh T, Thompson LK, Zhu S, Kuehfuss NM., Goetz JA, Gilbert SE, MacNair CR, Geddes-McAlister J, Brown ED, Cox G.

Reference: Nat. Chem. Biol. 2022 September 5; doi: 10.1038/s41589-022-01119-y

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

August 14, 2022

Authors: Weber BS, Carfrae LA, Woods JJ, Klobucar K, Bigham NP., MacNair CR, Raivio TL, Wilson JJ, Brown ED.

Reference: bioRxiv 2022 August 14; doi: 10.1101/2022.08.11.503708

Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli

August 3, 2022

Authors: Rachwalski K, Ellis MJ, Tong M, Brown ED.

Reference: MBio 2022 August 3; doi: 10.1128/mbio.01225-22

Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant

March 23, 2022

Authors: MacNair CR, Farha MA, Serrano-Wu MH, Lee KK, Hubbard B, Côté JP, Carfrae LA, Tu MM, Gaulin JL, Hunt DK, Hung DT, Brown ED.

Reference: ACS Infect. Dis. 2022 March 23; doi: 10.1021/acsinfecdis.1c00482

Transparent and Highly Flexible Hierarchically Structured Polydimethylsiloxane Surfaces Suppress Bacterial Attachment and Thrombosis Under Static and Dynamic Conditions

February 28, 2022

Authors: Khan S, Abu Jarad N, Ladouceur L, Rachwalski K, Bot V, Shakeri A, Maclachlan R, Sakib S, Weitz JI, Brown ED, Soleymani L, Didar TF.

Reference: Small 2022 February 28; doi: 10.1002/smll.202108112

New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance

February 1, 2022

Authors: Klobucar K, Brown ED.

Reference: Curr. Opin. Chem. Biol. 2022 February 1; doi: 10.1016/j.cbpa.2021.102099

Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery

January 21, 2022

Authors: Johnson JW, Ellis MJ, Piquette ZA, MacNair C, Carfrae L, Bhando T, Ritchie NE, Saliba P, Brown ED, Magolan J.

Reference: ACS Med. Chem. Lett. 2022 January 21; doi: 10.1021/acsmedchemlett.1c00648

Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria

September 2, 2021

Authors: Workman SD, Day J, Farha MA, El Zahed SS, Bon C, Brown ED, Organ MG, Strynadka, NC.

Reference: J. Med. Chem. 2021 September 2; doi: 10.1021/acs.jmedchem.1c00941

Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

July 21, 2021

Authors: Labana P, Dornan MH, Lafrenière, Czarny TL, Brown ED, Pexacki JP, Boddy CN.

Reference: Cell Chem. Biol. 2021 July 21; doi: 10.1016/j.chembiol.2021.07.001

A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse Beta-Lactam Resistance in MRSA

June 4, 2021

Authors: Bæk KT, Jensen C, Farha MA, Nielsen TK, Paknejadi E, Mebus VH, Vestergaard M, Brown ED, Frees D

Reference: Front. Mol. Biosci. 2021 June 4; doi: 10.3389/fmolb.2021.691569

Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane

May 11, 2021

Authors: Klobucar K, Côté JP, French S, Borrillo L, Guo ABY, Serrano-Wu MH, Lee KK, Hubbard B, Johnson JW, Gaulin JL, Magolan J, Hung DT, and Brown ED.

Reference: ACS Chem. Biol. 2021 May 11; doi: 10.1021/acschembio.1c00179