Two birds with one stone: Four DNA aptamers were isolated for Bcs1, a bifunctional enzyme that catalyzes both the reduction of ribulose 5-phosphate by using NADPH and cytidylyltransfer by using CTP. The inhibitory effects of these aptamers towards Bcs1 and their secondary structural properties were investigated (see scheme).


Allali-Hassani A, Pereira MP, Navani NK, Brown ED, Li Y.


Chembiochem. 2007 Nov 23;8(17):2052-7.