One piece at a time: Glycerol phosphate polymerization by the TagF enzyme is investigated through the use of a synthetic analogue of a teichoic acid intermediate. Analysis of polymerization products and reaction kinetics of the enzyme suggest a distributive assembly of the teichoic acid polymer on the TagB product lipid III.


Pereira MP, Schertzer JW, D'Elia MA, Koteva KP, Hughes DW, Wright GD, Brown ED.


Chembiochem. 2008 Jun 16;9(9):1385-90. doi: 10.1002/cbic.200800026