Flexible Hierarchical Wraps Repel Drug-Resistant Gram-Negative and Positive Bacteria

December 13, 2019

Authors: Imani SM, Maclachlan R, Rachwalski K, Chan Y, Lee L, McInnes M, Grandfield K, Brown ED, Didar TF, Soleymani L

Reference: ACS Nano. 2019 December 13; doi: 10.1021/acsnano.9b06287

Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA

November 25, 2019

Authors: El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED.

Reference: Nat. Chem. Biol. 2019 Nov 25; doi: 10.1038/s41589-019-0401-8

Creative targeting of the Gram‐negative outer membrane in antibiotic discovery

November 24, 2019

Authors: MacNair CR, Tsai CN, Brown ED.

Reference: Ann. N. Y. Acad. Sci. 2019 Nov 24; doi: 10.1111/nyas.14280

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

October 28, 2019

Authors: Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED.

Reference: Nat. Microbiol. 2019 Oct 28; doi: 10.1038/s41564-019-0595-2

Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane

September 30, 2019

Authors: French S, Farha M, Ellis MJ, Sameer Z, Côté JP, Cotroneo N, Lister T, Rubio A, Brown ED.
Reference: ACS Infect. Dis. 2019 Sept 30th; doi: 10.1021/acsinfecdis.9b00159

Drug repurposing for antimicrobial discovery.

March 4, 2019

Authors: Farha MA, Brown ED.
Reference: Nat. Microbiol. 2019 Mar 04; doi: 10.1038/s41564-019-0357-1

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

January 14, 2019

Authors: Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK and Brown ED.
Reference: Nat. Commun. 2019 Jan 14; doi: 10.1038/s41467-018-08190-x

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