Central metabolism is a key player in E. coli biofilm stimulation by sub-MIC antibiotics

September 15, 2022

Authors: Yaeger LN, French S, Brown ED, Côté JP, Burrows LL

Reference: bioRxiv 2022 September 15; doi: 10.1101/2022.09.14.507886

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria

September 13, 2022

Authors: Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED.

Reference: ACS Infect. Dis. 2022 September 13; doi: 10.1021/acsinfecdis.2c00357

A genetic platform to investigate the functions of bacterial drug efflux pumps

September 5, 2022

Authors:Teelucksingh T, Thompson LK, Zhu S, Kuehfuss NM., Goetz JA, Gilbert SE, MacNair CR, Geddes-McAlister J, Brown ED, Cox G.

Reference: Nat. Chem. Biol. 2022 September 5; doi: 10.1038/s41589-022-01119-y

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

August 14, 2022

Authors: Weber BS, Carfrae LA, Woods JJ, Klobucar K, Bigham NP., MacNair CR, Raivio TL, Wilson JJ, Brown ED.

Reference: bioRxiv 2022 August 14; doi: 10.1101/2022.08.11.503708

Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli

August 3, 2022

Authors: Rachwalski K, Ellis MJ, Tong M, Brown ED.

Reference: MBio 2022 August 3; doi: 10.1128/mbio.01225-22

Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant

March 23, 2022

Authors: MacNair CR, Farha MA, Serrano-Wu MH, Lee KK, Hubbard B, Côté JP, Carfrae LA, Tu MM, Gaulin JL, Hunt DK, Hung DT, Brown ED.

Reference: ACS Infect. Dis. 2022 March 23; doi: 10.1021/acsinfecdis.1c00482

Transparent and Highly Flexible Hierarchically Structured Polydimethylsiloxane Surfaces Suppress Bacterial Attachment and Thrombosis Under Static and Dynamic Conditions

February 28, 2022

Authors: Khan S, Abu Jarad N, Ladouceur L, Rachwalski K, Bot V, Shakeri A, Maclachlan R, Sakib S, Weitz JI, Brown ED, Soleymani L, Didar TF.

Reference: Small 2022 February 28; doi: 10.1002/smll.202108112

New potentiators of ineffective antibiotics: Targeting the Gram-negative outer membrane to overcome intrinsic resistance

February 1, 2022

Authors: Klobucar K, Brown ED.

Reference: Curr. Opin. Chem. Biol. 2022 February 1; doi: 10.1016/j.cbpa.2021.102099

Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery

January 21, 2022

Authors: Johnson JW, Ellis MJ, Piquette ZA, MacNair C, Carfrae L, Bhando T, Ritchie NE, Saliba P, Brown ED, Magolan J.

Reference: ACS Med. Chem. Lett. 2022 January 21; doi: 10.1021/acsmedchemlett.1c00648

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