Viewing entries tagged
ChemGen

A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor

April 23, 2024

Authors: French S, Guo ABY, Ellis MJ, Deisinger JP, Johnson JW, Rachwalski K, Piquette ZA, Lluka T, Zary M, Gamage S, Magolan J, Brown ED.

Reference: Cell Rep. 2024 April 23; doi:10.1016/j.celrep.2024.114053

A mobile CRISPRi collection enables genetic interaction studies for the essential genes of Escherichia coli

January 22, 2024

Authors: Rachwalski K, Tu MM, Madden SJ, French S, Hansen DM, Brown ED.

Reference: Cell Rep Methods. 2024 January 22; doi:10.1016/j.crmeth.2023.100693

Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae

July 21, 2020

Authors: Weber BS, De Jong AM, Guo ABY, Dharavath S, French S, Fiebig-Comyn AA, Coombes BK, Magnolan J, Brown ED.

Reference: Cell Rep. 2020 July 21; doi: 10.1016/j.celrep.2020.107927

A robust platform for chemical genomics in bacterial systems

March 15, 2016

Authors: French S, Mangat C, Bharat A, Côté JP, Mori H, Brown ED.
Reference: Mol Biol Cell. 2016 Mar 15;27(6):1015-25. doi: 10.1091/mbc.E15-08-0573. Epub 2016 Jan 20.