Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

March 6, 2017

Authors: Stokes JM, MacNair CR, Ilyas B, French S, Côté JP, Bouwman C, Farha MA, Sieron AO, Whitfield C, Coombes BK, Brown, ED.
Reference: Nature Microbiology. 2017 Mar 06;2(5):17028. doi:10.1038/nmicrobiol.2017.28

A cell-based approach to characterize antimicrobial compounds through kinetic dose response

December 15, 2016

Authors: MacNair CR, Stokes JM, French S, Myers CL, Iyer KR, Brown ED.
Reference: Bioorg Med Chem. 2016 Dec 15;24(24):6315-6319. doi: 10.1016/j.bmc.2016.09.053.

Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity.

February 18, 2016

Authors: Stokes JM, French S, Ovchinnikova OG, Bouwman C, Whitfield C, Brown ED.

Reference: Cell Chem Biol. 2016 Feb 18;23(2):267-77

Chemical modulators of ribosome biogenesis as biological probes

December 11, 2015

Authors: Stokes JM, Brown ED.
Reference: Nat Chem Biol. 2015 Dec;11(12):924-32. doi: 10.1038/nchembio.1957. Epub 2015 Nov 17.

Chemical inhibition of bacterial ribosome biogenesis shows efficacy in a worm infection model

May 1, 2015

Authors: Stokes JM, Selin C, Cardona ST, Brown ED.
Reference: Antimicrob Agents Chemother. 2015 May;59(5):2918-20. doi: 10.1128/AAC.04690-14. Epub 2015 Feb 23.

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

September 18, 2014

Authors: Stokes JM, Davis JH, Mangat CS, Williamson JR, Brown ED.
Reference: Elife. 2014 Sep 18;3:e03574. doi: 10.7554/eLife.03574.

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