Nutrient stress is a target for new antibiotics

January 27, 2023

Authors: Carfrae LA, Brown ED

Reference: Trends Microbiol. 2023 January 27; doi: 10.1016/j.tim.2023.01.002

CARD 2023: expanded curation, support for machine learning, and resistome prediction at the Comprehensive Antibiotic Resistance Database

January 6, 2023

Authors: Alcock BP, Huynh W … Bhando B, Carfrae LA, Farha MA, French S, Gordzevich R, Rachwalski K, Tu MM … Brown ED … McArthur AG.

Reference: Nucleic Acids Res. 2023 January 6; doi: 10.1093/nar/gkac920

Polynuclear ruthenium complexes are effective antibiotics against Pseudomonas aeruginosa

August 14, 2022

Authors: Weber BS, Carfrae LA, Woods JJ, Klobucar K, Bigham NP., MacNair CR, Raivio TL, Wilson JJ, Brown ED.

Reference: bioRxiv 2022 August 14; doi: 10.1101/2022.08.11.503708

Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant

March 23, 2022

Authors: MacNair CR, Farha MA, Serrano-Wu MH, Lee KK, Hubbard B, Côté JP, Carfrae LA, Tu MM, Gaulin JL, Hunt DK, Hung DT, Brown ED.

Reference: ACS Infect. Dis. 2022 March 23; doi: 10.1021/acsinfecdis.1c00482

Antibacterial Activity of Metergoline Analogues: Revisiting the Ergot Alkaloid Scaffold for Antibiotic Discovery

January 21, 2022

Authors: Johnson JW, Ellis MJ, Piquette ZA, MacNair C, Carfrae L, Bhando T, Ritchie NE, Saliba P, Brown ED, Magolan J.

Reference: ACS Med. Chem. Lett. 2022 January 21; doi: 10.1021/acsmedchemlett.1c00648

Overcoming Acquired and Native Macrolide Resistance with Bicarbonate

September 8, 2020

Authors: Farha MA, MacNair CR, Carfrae LA, El Zahed SS, Ellis MJ, Tran HKR, McArthur AG, Brown ED

Reference: ACS Infect. Dis. 2020 Sept 08; doi: 10.1021/acsinfecdis.0c00340

Uncovering the Hidden Antibiotic Potential of Cannabis

February 4, 2020

Authors: Farha MA*, El-Halfawy OM*, Gale RT, MacNair CR, Carfrae LA, Zhang X, Jentsch NG, Magolan J, Brown ED.

Reference: ACS Infect. Dis. 2020 Feb 04; doi: 10.1021/acsinfecdis.9b00419

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

October 28, 2019

Authors: Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED.

Reference: Nat. Microbiol. 2019 Oct 28; doi: 10.1038/s41564-019-0595-2

Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium

February 1, 2018

Authors: Ellis MJ, Carfrae LA, MacNair CR, Trussler RS, Brown ED, Haniford DB.
Reference: RNA Biol. 2018 Feb 1;15(2):176-181. doi: 10.1080/15476286.2017.1403001.

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

January 31, 2018

Authors: MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, Brown ED.
Reference: Nature Comm. 2018 Jan 31;9(1):458. doi:10.1038/s41467-018-02875-z

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