The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro.

September 2, 2005

Authors: Bhavsar AP, Truant R, Brown ED.
Reference: J Biol Chem. 2005 Nov 4;280(44):36691-700. Epub 2005 Sep 2.

Two conserved histidine residues are critical to the function of the TagF-like family of enzymes.

September 1, 2005

Authors: Schertzer JW, Bhavsar AP, Brown ED.
Reference: J Biol Chem. 2005 Nov 4;280(44):36683-90. Epub 2005 Sep 1.

Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function.

August 1, 2005

Authors: Campbell TL, Daigle DM, Brown ED.
Reference: Biochem J. 2005 Aug 1;389(Pt 3):843-52.

New targets and screening approaches in antimicrobial drug discovery.

February 1, 2005

Authors: Brown ED, Wright GD.
Reference: Chem Rev. 2005 Feb;105(2):759-74.

Probing the active site of YjeE: a vital Escherichia coli protein of unknown function.

December 15, 2004

Authors: Allali-Hassani A, Campbell TL, Ho A, Schertzer JW, Brown ED.
References: Biochem J. 2004 Dec 15;384(Pt 3):577-84.

Teichoic acid is an essential polymer in Bacillus subtilis that is functionally distinct from teichuronic acid.

December 1, 2004

Authors: Bhavsar AP, Erdman LK, Schertzer JW, Brown ED.
Reference: J Bacteriol. 2004 Dec;186(23):7865-73.

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.

October 1, 2004

Authors: Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED.
Reference: Chem Biol. 2004 Oct;11(10):1423-30.

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.

October 1, 2004

Authors: Blanchard JE, Elowe NH, Huitema C, Fortin PD, Cechetto JD, Eltis LD, Brown ED.
Reference: Chem Biol. 2004 Oct;11(10):1445-53

Drugs against superbugs: private lessons from bacteriophages.

September 1, 2004

Authors: Brown ED.
Reference: Trends Biotechnol. 2004 Sep;22(9):434-6.

An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase.

September 1, 2004

Authors: Mayer S, Daigle DM, Brown ED, Khatri J, Organ MG.
Reference: J Comb Chem. 2004 Sep-Oct;6(5):776-82.

Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus.

August 27, 2004

Authors: Pereira MP, Brown ED.
Reference: Biochemistry. 2004 Sep 21;43(37):11802-12

Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro.

March 1, 2004

Authors: Daigle DM, Brown ED.
Reference: J Bacteriol. 2004 Mar;186(5):1381-7.

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.

August 4, 2003

Authors: Zolli-Juran M, Cechetto JD, Hartlen R, Daigle DM, Brown ED.
Reference: Bioorg Med Chem Lett. 2003 Aug 4;13(15):2493-6.

Screening in academe: a perspective on implementation of university-based small molecule screening.

August 1, 2003

Authors: Brown ED.
Reference: J Biomol Screen. 2003 Aug;8(4):377-9.

Purified, recombinant TagF protein from Bacillus subtilis 168 catalyzes the polymerization of glycerol phosphate onto a membrane acceptor in vitro.

May 16, 2003

Authors: Schertzer JW, Brown ED.
Reference: J Biol Chem. 2003 May 16;278(20):18002-7. Epub 2003 Mar 12

CTP:glycerol 3-phosphate cytidylyltransferase (TarD) from Staphylococcus aureus catalyzes the cytidylyl transfer via an ordered Bi-Bi reaction mechanism with micromolar K(m) values.

March 21, 2003

Authors: Badurina DS, Zolli-Juran M, Brown ED.
Reference: Biochim Biophys Acta. 2003 Mar 21;1646(1-2):196-206.

Characterization of the depletion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase in Escherichia coli and Bacillus subtilis.

October 1, 2002

Authors: Campbell TL, Brown ED.
Reference: J Bacteriol. 2002 Oct;184(20):5609-18.

YjeQ, an essential, conserved, uncharacterized protein from Escherichia coli, is an unusual GTPase with circularly permuted G-motifs and marked burst kinetics.

September 17, 2002

Authors: Daigle DM, Rossi L, Berghuis AM, Aravind L, Koonin EV, Brown ED.
Reference: Biochemistry. 2002 Sep 17;41(37):11109-17.

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