Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms.

June 1, 2006

Authors: Bhavsar AP, Brown ED.
Reference: Mol Microbiol. 2006 Jun;60(5):1077-90.

Microbiology: antibiotic stops 'ping-pong' match.

May 18, 2006

Authors: Brown ED.
Reference: Nature. 2006 May 18;441(7091):293-4.

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.

January 1, 2006

Authors: Fong DH, Yim VC, D'Elia MA, Brown ED, Berghuis AM.
Reference: Biochim Biophys Acta. 2006 Jan;1764(1):63-9. Epub 2005 Nov 10.

Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology.

December 1, 2005

Authors: Brown ED.
Reference: Biochem Cell Biol. 2005 Dec;83(6):738-46. Review.

Experimental screening of dihydrofolate reductase yields a "test set" of 50,000 small molecules for a computational data-mining and docking competition.

September 16, 2005

Authors: Elowe NH, Blanchard JE, Cechetto JD, Brown ED.
Reference: J Biomol Screen. 2005 Oct;10(7):653-7. Epub 2005 Sep 16.

The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro.

September 2, 2005

Authors: Bhavsar AP, Truant R, Brown ED.
Reference: J Biol Chem. 2005 Nov 4;280(44):36691-700. Epub 2005 Sep 2.

Two conserved histidine residues are critical to the function of the TagF-like family of enzymes.

September 1, 2005

Authors: Schertzer JW, Bhavsar AP, Brown ED.
Reference: J Biol Chem. 2005 Nov 4;280(44):36683-90. Epub 2005 Sep 1.

Characterization of the Bacillus subtilis GTPase YloQ and its role in ribosome function.

August 1, 2005

Authors: Campbell TL, Daigle DM, Brown ED.
Reference: Biochem J. 2005 Aug 1;389(Pt 3):843-52.

New targets and screening approaches in antimicrobial drug discovery.

February 1, 2005

Authors: Brown ED, Wright GD.
Reference: Chem Rev. 2005 Feb;105(2):759-74.

Probing the active site of YjeE: a vital Escherichia coli protein of unknown function.

December 15, 2004

Authors: Allali-Hassani A, Campbell TL, Ho A, Schertzer JW, Brown ED.
References: Biochem J. 2004 Dec 15;384(Pt 3):577-84.

Teichoic acid is an essential polymer in Bacillus subtilis that is functionally distinct from teichuronic acid.

December 1, 2004

Authors: Bhavsar AP, Erdman LK, Schertzer JW, Brown ED.
Reference: J Bacteriol. 2004 Dec;186(23):7865-73.

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.

October 1, 2004

Authors: Li X, Zolli-Juran M, Cechetto JD, Daigle DM, Wright GD, Brown ED.
Reference: Chem Biol. 2004 Oct;11(10):1423-30.

High-throughput screening identifies inhibitors of the SARS coronavirus main proteinase.

October 1, 2004

Authors: Blanchard JE, Elowe NH, Huitema C, Fortin PD, Cechetto JD, Eltis LD, Brown ED.
Reference: Chem Biol. 2004 Oct;11(10):1445-53

Drugs against superbugs: private lessons from bacteriophages.

September 1, 2004

Authors: Brown ED.
Reference: Trends Biotechnol. 2004 Sep;22(9):434-6.

An expedient and facile one-step synthesis of a biguanide library by microwave irradiation coupled with simple product filtration. Inhibitors of dihydrofolate reductase.

September 1, 2004

Authors: Mayer S, Daigle DM, Brown ED, Khatri J, Organ MG.
Reference: J Comb Chem. 2004 Sep-Oct;6(5):776-82.

Bifunctional catalysis by CDP-ribitol synthase: convergent recruitment of reductase and cytidylyltransferase activities in Haemophilus influenzae and Staphylococcus aureus.

August 27, 2004

Authors: Pereira MP, Brown ED.
Reference: Biochemistry. 2004 Sep 21;43(37):11802-12

Studies of the interaction of Escherichia coli YjeQ with the ribosome in vitro.

March 1, 2004

Authors: Daigle DM, Brown ED.
Reference: J Bacteriol. 2004 Mar;186(5):1381-7.

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.

August 4, 2003

Authors: Zolli-Juran M, Cechetto JD, Hartlen R, Daigle DM, Brown ED.
Reference: Bioorg Med Chem Lett. 2003 Aug 4;13(15):2493-6.

Screening in academe: a perspective on implementation of university-based small molecule screening.

August 1, 2003

Authors: Brown ED.
Reference: J Biomol Screen. 2003 Aug;8(4):377-9.

Purified, recombinant TagF protein from Bacillus subtilis 168 catalyzes the polymerization of glycerol phosphate onto a membrane acceptor in vitro.

May 16, 2003

Authors: Schertzer JW, Brown ED.
Reference: J Biol Chem. 2003 May 16;278(20):18002-7. Epub 2003 Mar 12

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