Zinc Chelation by a Small-Molecule Adjuvant Potentiates Meropenem Activity in Vivo against NDM-1-Producing Klebsiella pneumoniae

December 31, 2015

Authors: Falconer SB, Reid-Yu SA, King AM, Gehrke SS, Wang W, Britten JF, Coombes BK, Wright GD, Brown ED.
Reference: ACS Infect Dis. 2015 Nov 13;1(11):533-43. doi: 10.1021/acsinfecdis.5b00033.

Chemical modulators of ribosome biogenesis as biological probes

December 11, 2015

Authors: Stokes JM, Brown ED.
Reference: Nat Chem Biol. 2015 Dec;11(12):924-32. doi: 10.1038/nchembio.1957. Epub 2015 Nov 17.

Gram-Negative Resistance

November 13, 2015

Authors: Brown ED.
Reference: ACS Infect Dis. 2015 Nov 13;1(11):507. doi: 10.1021/acsinfecdis.5b00123.

New chemical tools to probe cell wall biosynthesis in bacteria

October 27, 2015

Authors: Gale RT, Brown ED
References: Curr Opin Microbiol. 2015 Oct;27:69-77. doi: 10.1016/j.mib.2015.07.013. Epub 2015 Aug 25.

Editorial overview: Microbial systems biology.

October 27, 2015

Authors: Brown ED, Typas A.
Reference: Curr Opin Microbiol. 2015 Oct;27:viii-ix. doi: 10.1016/j.mib.2015.09.007. Epub 2015 Oct 20.

Unconventional screening approaches for antibiotic discovery.

September 13, 2015

Authors: Farha MA, Brown ED.
Reference: Ann N Y Acad Sci. 2015 Sep;1354:54-66. doi: 10.1111/nyas.12803. Epub 2015 Jun 22.

Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase

September 1, 2015

Authors: Farha MA, Czarny TL, Myers CL, Worrall LJ, French S, Conrady DG, Wang Y, Oldfield E, Strynadka NC, Brown ED.
Reference: Proc Natl Acad Sci U S A. 2015 Sep 1;112(35):11048-53. doi: 10.1073/pnas.1511751112. Epub 2015 Aug 17.

An electron transfer flavoprotein is essential for viability and its depletion causes a rod-to-sphere change in Burkholderia cenocepacia.

August 6, 2015

Authors: Bloodworth RA, Zlitni S, Brown ED, Cardona ST.
Reference: Microbiology. 2015 Oct;161(10):1909-20. doi: 10.1099/mic.0.000156. Epub 2015 Aug 6.

Characterization of Wall Teichoic Acid Degradation by the Bacteriophage ϕ29 Appendage Protein GP12 Using Synthetic Substrate Analogs

July 31, 2015

Authors: Myers CL, Ireland RG, Garrett TA, Brown ED.
Reference: J Biol Chem. 2015 Jul 31;290(31):19133-45. doi: 10.1074/jbc.M115.662866. Epub 2015 Jun 17.

A Pipeline for Screening Small Molecules with Growth Inhibitory Activity against Burkholderia cenocepacia

June 8, 2015

Authors: Selin C, Stietz MS, Blanchard JE, Gehrke SS, Bernard S, Hall DG, Brown ED, Cardona ST.
Reference: PLoS One. 2015 Jun 8;10(6):e0128587. doi: 10.1371/journal.pone.0128587. eCollection 2015.

Chemical inhibition of bacterial ribosome biogenesis shows efficacy in a worm infection model

May 1, 2015

Authors: Stokes JM, Selin C, Cardona ST, Brown ED.
Reference: Antimicrob Agents Chemother. 2015 May;59(5):2918-20. doi: 10.1128/AAC.04690-14. Epub 2015 Feb 23.

Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid α-glycosyltransferase.

February 10, 2015

Authors: Sobhanifar S, Worrall LJ, Gruninger RJ, Wasney GA, Blaukopf M, Baumann L, Lameignere E, Solomonson M, Brown ED, Withers SG, Strynadka NC.
Reference: Proc Natl Acad Sci U S A. 2015 Feb 10;112(6):E576-85. doi: 10.1073/pnas.1418084112. Epub 2015 Jan 26.

A dual reporter system for detecting RNA interactions in bacterial cells.

December 15, 2014

Authors: Kuryllo K, Jahanshahi S, Zhu W, Brown ED, Li Y.
Reference: Chembiochem. 2014 Dec 15;15(18):2703-9. doi: 10.1002/cbic.201402322. Epub 2014 Oct 30.

Rank ordering plate data facilitates data visualization and normalization in high-throughput screening

October 19, 2014

Authors: Mangat CS, Bharat A, Gehrke SS, Brown ED.
Reference: J Biomol Screen. 2014 Oct;19(9):1314-20. doi: 10.1177/1087057114534298. Epub 2014 May 14.

Discovery of a small molecule that inhibits bacterial ribosome biogenesis

September 18, 2014

Authors: Stokes JM, Davis JH, Mangat CS, Williamson JR, Brown ED.
Reference: Elife. 2014 Sep 18;3:e03574. doi: 10.7554/eLife.03574.

Discovery of novel cell wall-active compounds using PywaC, a sensitive reporter of cell wall stress, in the model gram-positive bacterium Bacillus subtilis

June 1, 2014

Authors: Czarny TL, Perri AL, French S, Brown ED
Reference: Antimicrob Agents Chemother. 2014 Jun;58(6):3261-9. doi: 10.1128/AAC.02352-14

Phenotypic investigations of the depletion of EngA in Escherichia coli are consistent with a role in ribosome biogenesis

April 1, 2014

Authors: Bharat A, Brown ED.
Reference: FEMS Microbiol Lett. 2014 Apr;353(1):26-32.

Designing analogs of ticlopidine, a wall teichoic acid inhibitor, to avoid formation of its oxidative metabolites.

February 1, 2014

Authors: Farha MA, Koteva K, Gale RT, Sewell EW, Wright GD, Brown ED.
Reference: Bioorg Med Chem Lett. 2014 Feb 1;24(3):905-10. doi: 10.1016/j.bmcl.2013.12.069. Epub 2013 Dec 23.

Metal-induced isomerization yields an intracellular chelator that disrupts bacterial iron homeostasis

January 16, 2014

Authors: Falconer SB, Wang W, Gehrke SS, Cuneo JD, Britten JF, Wright GD, Brown ED.
Reference: Chem Biol. 2014 Jan 16;21(1):136-45. doi: 10.1016/j.chembiol.2013.11.007. Epub 2013 Dec 19.

Exploring intermolecular interactions of a substrate binding protein using a riboswitch-based sensor

December 19, 2013

Authors: Fowler CC, Sugiman-Marangos S, Junop MS, Brown ED, Li Y.
Reference: Chem Biol. 2013 Dec 19;20(12):1502-12. doi: 10.1016/j.chembiol.2013.10.014. Epub 2013 Nov 27.

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