Nutrient Stress Small-Molecule Screening Platform for Escherichia coli

May 14, 2018

Authors: El Zahed SS, Kumar G, Tong M, Brown ED.
Reference: Bridget Wagner (ed.), Phenotypic Screening: Methods and Protocols, Methods in Molecular Biology, vol. 1787, doi:10.1007/978-1-4939-7847-2_1

Chemical-Chemical Combinations Map Uncharted Interactions in Escherichia coli under Nutrient Stress

March 27, 2018

Authors: El Zahed SS, Brown ED.
Reference: iScience. 2018 Mar 27; doi: 10.1016/j.isci.2018.03.018.

Silent but deadly: IS200 promotes pathogenicity in Salmonella Typhimurium

February 1, 2018

Authors: Ellis MJ, Carfrae LA, MacNair CR, Trussler RS, Brown ED, Haniford DB.
Reference: RNA Biol. 2018 Feb 1;15(2):176-181. doi: 10.1080/15476286.2017.1403001.

Overcoming mcr-1 mediated colistin resistance with colistin in combination with other antibiotics

January 31, 2018

Authors: MacNair CR, Stokes JM, Carfrae LA, Fiebig-Comyn AA, Coombes BK, Mulvey MR, Brown ED.
Reference: Nature Comm. 2018 Jan 31;9(1):458. doi:10.1038/s41467-018-02875-z

B. subtilis LytR-CpsA-Psr Enzymes Transfer Wall Teichoic Acids from Authentic Lipid-Linked Substrates to Mature Peptidoglycan In Vitro

December 21, 2017

Authors: Gale RT, Li KKL, Sun T, Strynadka NCJ, Brown ED.
Reference: Cell Chem Biol. 2017 Dec 1;24(12):1537-1546. doi: 10.1016/j.chembiol.2017.09.006.

Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force

December 21, 2017

Authors: Farha MA, French S, Stokes JM, Brown ED.
Reference: ACS Infect Dis. 2017 Dec 21;4(3):382-390. doi: 10.1021/acsinfecdis.7b00194.

Exploiting the sensitivity of nutrient transporter deletion strains in discovery of natural product antimetabolites

October 25, 2017

Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD,
Reference: ACS Infect Dis. 2017 Oct 25;3(12):955-965. doi: 10.1021/acsinfecdis.7b00149.

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

October 24, 2017

Authors: Klobucar K, Brown ED.
Reference: FEMS Microbiol Rev. 2017 Oct 24;42(1):fux054. doi: 10.1093/femsre/fux054.

Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria

October 1, 2017

Authors: French S, Ellis MJ, Coutts BE, Brown ED.
Reference: Curr Opin Microbiol. 2017 Sept 26;39:42-47. doi: 10.1016/j.mib.2017.09.005

Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology

March 7, 2017

Authors: French S, Côté JP, Stokes JM, Truant R, Brown ED.
Reference: mBio. 2017 Mar 7;8(2):e01977-16. doi: 10.1128/mBio.01977-16

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

March 6, 2017

Authors: Stokes JM, MacNair CR, Ilyas B, French S, Côté JP, Bouwman C, Farha MA, Sieron AO, Whitfield C, Coombes BK, Brown, ED.
Reference: Nature Microbiology. 2017 Mar 06;2(5):17028. doi:10.1038/nmicrobiol.2017.28

A cell-based approach to characterize antimicrobial compounds through kinetic dose response

December 15, 2016

Authors: MacNair CR, Stokes JM, French S, Myers CL, Iyer KR, Brown ED.
Reference: Bioorg Med Chem. 2016 Dec 15;24(24):6315-6319. doi: 10.1016/j.bmc.2016.09.053.

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance

December 14, 2016

Authors: Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC.
Reference: PLoS Pathog. 2016 Dec 14;12(12):e1006067. doi: 10.1371/journal.ppat.1006067.

Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component.

December 9, 2016

Authors: Myers CL, Li FK, Koo BM, El-Halfawy OM, French S, Gross CA, Strynadka NC, Brown ED.
Reference: J Biol Chem. 2016 Dec 9;291(50):26066-26082.

The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli

November 22, 2016

Authors: Côté JP, French S, Gehrke SS, MacNair CR, Mangat CS, Bharat A, Brown ED.
Reference: MBio. 2016 Nov 22;7(6). pii: e01714-16. doi: 10.1128/mBio.01714-16.

Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery

October 11, 2016

Authros: Gagarinova A, Stewart G, Samanfar B, Phanse S, White CA, Aoki H, Deineko V, Beloglazova N, Yakunin AF, Golshani A, Brown ED, Babu M, Emili A.
Reference: Cell Rep. 2016 Oct 11;17(3):904-916. doi: 10.1016/j.celrep.2016.09.040.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

June 2, 2016

Authors: Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CH, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA
Reference: Cell. 2016 Jun 2;165(6):1493-506

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System.

May 23, 2016

Authors: Poole K, Gilmour C, Farha MA, Mullen E, Lau CH, Brown ED.

Reference: Antimicrob Agents Chemother. 2016 May 23;60(6):3509-18.

A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase

May 7, 2016

Authors: Tomasz L. Czarny, Eric D. Brown

Reference: ACS Infect. Dis. May 7 2016, DOI: 10.1021/acsinfecdis.6b00044

Strategies for target identification of antimicrobial natural products

May 4, 2016

Authors: Farha MA, Brown ED
Reference: Nat Prod Rep. 2016 May 4;33(5):668-80. doi: 10.1039/c5np00127g.

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