Structural Insights into the Inhibition of Undecaprenyl Pyrophosphate Synthase from Gram-Positive Bacteria

September 2, 2021

Authors: Workman SD, Day J, Farha MA, El Zahed SS, Bon C, Brown ED, Organ MG, Strynadka, NC.

Reference: J. Med. Chem. 2021 September 2; doi: 10.1021/acs.jmedchem.1c00941

Armeniaspirols inhibit the AAA+ proteases ClpXP and ClpYQ leading to cell division arrest in Gram-positive bacteria

July 21, 2021

Authors: Labana P, Dornan MH, Lafrenière, Czarny TL, Brown ED, Pexacki JP, Boddy CN.

Reference: Cell Chem. Biol. 2021 July 21; doi: 10.1016/j.chembiol.2021.07.001

A Staphylococcus aureus clpX Mutant Used as a Unique Screening Tool to Identify Cell Wall Synthesis Inhibitors that Reverse Beta-Lactam Resistance in MRSA

June 4, 2021

Authors: Bæk KT, Jensen C, Farha MA, Nielsen TK, Paknejadi E, Mebus VH, Vestergaard M, Brown ED, Frees D

Reference: Front. Mol. Biosci. 2021 June 4; doi: 10.3389/fmolb.2021.691569

Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane

May 11, 2021

Authors: Klobucar K, Côté JP, French S, Borrillo L, Guo ABY, Serrano-Wu MH, Lee KK, Hubbard B, Johnson JW, Gaulin JL, Magolan J, Hung DT, and Brown ED.

Reference: ACS Chem. Biol. 2021 May 11; doi: 10.1021/acschembio.1c00179

Crystallographic analysis of TarI and TarJ, a cytidylyltransferase and reductase pair for CDP-ribitol synthesis in Staphylococcus aureus wall teichoic acid biogenesis

April 2, 2021

Authors: Li KKF, Gale RT, Petrochenko EV, Borchers CH, Brown ED, Strynadka NCJ.

Reference: JSB 2021 April 2; doi: 10.1016/j.jsb.2021.107733

Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery

March 31, 2021

Authors: Farha MA, French S, and Brown ED.

Reference: Acc. Chem. Res.. 2021 Mar 31; doi: 10.1021/acs.accounts.1c00011

Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli

January 19, 2021

Authors: El Zahed SS, French S, Farha MA, Kumar G, and Brown ED.

Reference: AAC. 2021 Jan 19; doi: 10.1128/AAC.01925-20.

Publications