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Nutrient stress is a target for new antibiotics

January 27, 2023

Authors: Carfrae LA, Brown ED

Reference: Trends Microbiol. 2023 January 27; doi: 10.1016/j.tim.2023.01.002

Genetic and Chemical Screening Reveals Targets and Compounds to Potentiate Gram-Positive Antibiotics against Gram-Negative Bacteria

September 13, 2022

Authors: Klobucar K, Jardine E, Farha MA, MacKinnon MR, Fragis M, Nkonge B, Bhando T, Borrillo L, Tsai CN, Johnson JW, Coombes BK, Magolan J, Brown ED.

Reference: ACS Infect. Dis. 2022 September 13; doi: 10.1021/acsinfecdis.2c00357

Synthetic Genetic Interactions Reveal a Dense and Cryptic Regulatory Network of Small Noncoding RNAs in Escherichia coli

August 3, 2022

Authors: Rachwalski K, Ellis MJ, Tong M, Brown ED.

Reference: MBio 2022 August 3; doi: 10.1128/mbio.01225-22

Preclinical Development of Pentamidine Analogs Identifies a Potent and Nontoxic Antibiotic Adjuvant

March 23, 2022

Authors: MacNair CR, Farha MA, Serrano-Wu MH, Lee KK, Hubbard B, Côté JP, Carfrae LA, Tu MM, Gaulin JL, Hunt DK, Hung DT, Brown ED.

Reference: ACS Infect. Dis. 2022 March 23; doi: 10.1021/acsinfecdis.1c00482

Chemical Screen for Vancomycin Antagonism Uncovers Probes of the Gram-Negative Outer Membrane

May 11, 2021

Authors: Klobucar K, Côté JP, French S, Borrillo L, Guo ABY, Serrano-Wu MH, Lee KK, Hubbard B, Johnson JW, Gaulin JL, Magolan J, Hung DT, and Brown ED.

Reference: ACS Chem. Biol. 2021 May 11; doi: 10.1021/acschembio.1c00179

Systems-Level Chemical Biology to Accelerate Antibiotic Drug Discovery

March 31, 2021

Authors: Farha MA, French S, and Brown ED.

Reference: Acc. Chem. Res.. 2021 Mar 31; doi: 10.1021/acs.accounts.1c00011

Physicochemical and Structural Parameters Contributing to the Antibacterial Activity and Efflux Susceptibility of Small-Molecule Inhibitors of Escherichia coli

January 19, 2021

Authors: El Zahed SS, French S, Farha MA, Kumar G, and Brown ED.

Reference: AAC. 2021 Jan 19; doi: 10.1128/AAC.01925-20.

Gene Dispensability in Escherichia coli Grown in Thirty Different Carbon Environments

September 29, 2020

Authors: Tong M, French S, El Zahed SS, Ong WK, Karp PD, Brown ED

Reference: mBio. 2020 Sept 29; doi: 10.1128/mBio.02259-20

Outer Membrane Disruption Overcomes Intrinsic, Acquired, and Spontaneous Antibiotic Resistance

September 22, 2020

Authors: MacNair CR, Brown ED

Reference: mBio. 2020 Sept 22; doi: 10.1128/mBio.01615-20

Overcoming Acquired and Native Macrolide Resistance with Bicarbonate

September 8, 2020

Authors: Farha MA, MacNair CR, Carfrae LA, El Zahed SS, Ellis MJ, Tran HKR, McArthur AG, Brown ED

Reference: ACS Infect. Dis. 2020 Sept 08; doi: 10.1021/acsinfecdis.0c00340

Genetic and Chemical Screening in Human Blood Serum Reveals Unique Antibacterial Targets and Compounds against Klebsiella pneumoniae

July 21, 2020

Authors: Weber BS, De Jong AM, Guo ABY, Dharavath S, French S, Fiebig-Comyn AA, Coombes BK, Magnolan J, Brown ED.

Reference: Cell Rep. 2020 July 21; doi: 10.1016/j.celrep.2020.107927

Genetic and Chemical-Genetic Interactions Map Biogenesis and Permeability Determinants of the Outer Membrane of Escherichia coli

March 10, 2020

Authors: Klobucar K, French S, Côté JP, Howes JR, Brown ED

Reference: mBio. 2020 Mar 10; doi: 10.1128/mBio.00161-20

Uncovering the Hidden Antibiotic Potential of Cannabis

February 4, 2020

Authors: Farha MA*, El-Halfawy OM*, Gale RT, MacNair CR, Carfrae LA, Zhang X, Jentsch NG, Magolan J, Brown ED.

Reference: ACS Infect. Dis. 2020 Feb 04; doi: 10.1021/acsinfecdis.9b00419

A comprehensive guide to dynamic analysis of microbial gene expression using the 3D-printed PFIbox and a fluorescent reporter library

January 8, 2020

Authors: French S, Guo ABY, Brown ED.

Reference: Nat. Protoc. 2020 Jan 08; doi: 10.1038/s41596-019-0257-0

Discovery of an antivirulence compound that reverses β-lactam resistance in MRSA

November 25, 2019

Authors: El-Halfawy OM, Czarny TL, Flannagan RS, Day J, Bozelli JC, Kuiack RC, Salim A, Eckert P, Epand RM, McGavin MJ, Organ MG, Heinrichs DE, Brown ED.

Reference: Nat. Chem. Biol. 2019 Nov 25; doi: 10.1038/s41589-019-0401-8

Mimicking the human environment in mice reveals that inhibiting biotin biosynthesis is effective against antibiotic-resistant pathogens

October 28, 2019

Authors: Carfrae LA, MacNair CR, Brown CM, Tsai CN, Weber BS, Zlitni S, Rao VN, Chun J, Junop MS, Coombes BK, Brown ED.

Reference: Nat. Microbiol. 2019 Oct 28; doi: 10.1038/s41564-019-0595-2

Potentiation of Antibiotics against Gram-Negative Bacteria by Polymyxin B Analogue SPR741 from Unique Perturbation of the Outer Membrane

September 30, 2019

Authors: French S, Farha M, Ellis MJ, Sameer Z, Côté JP, Cotroneo N, Lister T, Rubio A, Brown ED.
Reference: ACS Infect. Dis. 2019 Sept 30th; doi: 10.1021/acsinfecdis.9b00159

A macrophage-based screen identifies antibacterial compounds selective for intracellular Salmonella Typhimurium

January 14, 2019

Authors: Ellis MJ, Tsai CN, Johnson JW, French S, Elhenawy W, Porwollik S, Andrews-Polymenis H, McClelland M, Magolan J, Coombes BK and Brown ED. 
Reference: Nat. Commun. 2019 Jan 14; doi: 10.1038/s41467-018-08190-x

Open-Source High-Throughput Phenomics of Bacterial Promoter-Reporter Strains

August 29, 2018

Authors: French S, Coutts BE, Brown ED.
Reference: Cell Syst. 2018. Aug 29; doi:10.1016/j.cels.2018.07.004

Chemical-Chemical Combinations Map Uncharted Interactions in Escherichia coli under Nutrient Stress

March 27, 2018

Authors: El Zahed SS, Brown ED.
Reference: iScience. 2018 Mar 27; doi: 10.1016/j.isci.2018.03.018.