Bicarbonate alters bacterial susceptibility to antibiotics by targeting the proton motive force

December 21, 2017

Authors: Farha MA, French S, Stokes JM, Brown ED.
Reference: ACS Infect Dis. 2017 Dec 21;4(3):382-390. doi: 10.1021/acsinfecdis.7b00194.

Exploiting the sensitivity of nutrient transporter deletion strains in discovery of natural product antimetabolites

October 25, 2017

Authors: Gehrke SS, Kumar G, Yokubynas NA, Côté JP, Wang W, French S, MacNair CR, Wright GD,
Reference: ACS Infect Dis. 2017 Oct 25;3(12):955-965. doi: 10.1021/acsinfecdis.7b00149.

Use of genetic and chemical synthetic lethality as probes of complexity in bacterial cell systems

October 24, 2017

Authors: Klobucar K, Brown ED.
Reference: FEMS Microbiol Rev. 2017 Oct 24;42(1):fux054. doi: 10.1093/femsre/fux054.

Chemical genomics reveals mechanistic hypotheses for uncharacterized bioactive molecules in bacteria

October 1, 2017

Authors: French S, Ellis MJ, Coutts BE, Brown ED.
Reference: Curr Opin Microbiol. 2017 Sept 26;39:42-47. doi: 10.1016/j.mib.2017.09.005

Bacteria Getting into Shape: Genetic Determinants of E. coli Morphology

March 7, 2017

Authors: French S, Côté JP, Stokes JM, Truant R, Brown ED.
Reference: mBio. 2017 Mar 7;8(2):e01977-16. doi: 10.1128/mBio.01977-16

Pentamidine sensitizes Gram-negative pathogens to antibiotics and overcomes acquired colistin resistance

March 6, 2017

Authors: Stokes JM, MacNair CR, Ilyas B, French S, Côté JP, Bouwman C, Farha MA, Sieron AO, Whitfield C, Coombes BK, Brown, ED.
Reference: Nature Microbiology. 2017 Mar 06;2(5):17028. doi:10.1038/nmicrobiol.2017.28

A cell-based approach to characterize antimicrobial compounds through kinetic dose response

December 15, 2016

Authors: MacNair CR, Stokes JM, French S, Myers CL, Iyer KR, Brown ED.
Reference: Bioorg Med Chem. 2016 Dec 15;24(24):6315-6319. doi: 10.1016/j.bmc.2016.09.053.

Structure and Mechanism of Staphylococcus aureus TarS, the Wall Teichoic Acid β-glycosyltransferase Involved in Methicillin Resistance

December 14, 2016

Authors: Sobhanifar S, Worrall LJ, King DT, Wasney GA, Baumann L, Gale RT, Nosella M, Brown ED, Withers SG, Strynadka NC.
Reference: PLoS Pathog. 2016 Dec 14;12(12):e1006067. doi: 10.1371/journal.ppat.1006067.

Identification of Two Phosphate Starvation-induced Wall Teichoic Acid Hydrolases Provides First Insights into the Degradative Pathway of a Key Bacterial Cell Wall Component.

December 9, 2016

Authors: Myers CL, Li FK, Koo BM, El-Halfawy OM, French S, Gross CA, Strynadka NC, Brown ED.
Reference: J Biol Chem. 2016 Dec 9;291(50):26066-26082.

The Genome-Wide Interaction Network of Nutrient Stress Genes in Escherichia coli

November 22, 2016

Authors: Côté JP, French S, Gehrke SS, MacNair CR, Mangat CS, Bharat A, Brown ED.
Reference: MBio. 2016 Nov 22;7(6). pii: e01714-16. doi: 10.1128/mBio.01714-16.

Systematic Genetic Screens Reveal the Dynamic Global Functional Organization of the Bacterial Translation Machinery

October 11, 2016

Authros: Gagarinova A, Stewart G, Samanfar B, Phanse S, White CA, Aoki H, Deineko V, Beloglazova N, Yakunin AF, Golshani A, Brown ED, Babu M, Emili A.
Reference: Cell Rep. 2016 Oct 11;17(3):904-916. doi: 10.1016/j.celrep.2016.09.040.

A Comprehensive, CRISPR-based Functional Analysis of Essential Genes in Bacteria

June 2, 2016

Authors: Peters JM, Colavin A, Shi H, Czarny TL, Larson MH, Wong S, Hawkins JS, Lu CH, Koo BM, Marta E, Shiver AL, Whitehead EH, Weissman JS, Brown ED, Qi LS, Huang KC, Gross CA
Reference: Cell. 2016 Jun 2;165(6):1493-506

Potentiation of Aminoglycoside Activity in Pseudomonas aeruginosa by Targeting the AmgRS Envelope Stress-Responsive Two-Component System.

May 23, 2016

Authors: Poole K, Gilmour C, Farha MA, Mullen E, Lau CH, Brown ED.

Reference: Antimicrob Agents Chemother. 2016 May 23;60(6):3509-18.

A Small-Molecule Screening Platform for the Discovery of Inhibitors of Undecaprenyl Diphosphate Synthase

May 7, 2016

Authors: Tomasz L. Czarny, Eric D. Brown

Reference: ACS Infect. Dis. May 7 2016, DOI: 10.1021/acsinfecdis.6b00044

Strategies for target identification of antimicrobial natural products

May 4, 2016

Authors: Farha MA, Brown ED
Reference: Nat Prod Rep. 2016 May 4;33(5):668-80. doi: 10.1039/c5np00127g.

Structural and Kinetic Characterization of Diazabicyclooctanes as Dual Inhibitors of Both Serine-β-Lactamases and Penicillin-Binding Proteins

April 15, 2016

Authors: King AM, King DT, French S, Brouillette E, Asli A, Alexander JA, Vuckovic M, Maiti SN, Parr TR Jr, Brown ED, Malouin F, Strynadka NC, Wright GD.

Reference: ACS Chem Biol. 2016 Apr 15;11(4):864-8. doi: 10.1021/acschembio.5b00944. Epub 2016 Jan 14.

Assembly and clustering of natural antibiotics guides target identification.

April 12, 2016

Authors: Johnston CW, Skinnider MA, Dejong CA, Rees PN, Chen GM, Walker CG, French S, Brown ED, Bérdy J, Liu DY, Magarvey NA.

Reference: Nat Chem Biol. 2016 Apr;12(4):233-9. doi: 10.1038/nchembio.2018. Epub 2016 Feb 1.

A robust platform for chemical genomics in bacterial systems

March 15, 2016

Authors: French S, Mangat C, Bharat A, Côté JP, Mori H, Brown ED.
Reference: Mol Biol Cell. 2016 Mar 15;27(6):1015-25. doi: 10.1091/mbc.E15-08-0573. Epub 2016 Jan 20.

Cold Stress Makes Escherichia coli Susceptible to Glycopeptide Antibiotics by Altering Outer Membrane Integrity.

February 18, 2016

Authors: Stokes JM, French S, Ovchinnikova OG, Bouwman C, Whitfield C, Brown ED.

Reference: Cell Chem Biol. 2016 Feb 18;23(2):267-77

Antibacterial drug discovery in the resistance era

January 21, 2016

Authors: Brown ED, Wright GD.
Reference: Nature. 2016 Jan 21;529(7586):336-43. doi: 10.1038/nature17042.

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