Small and lethal: searching for new antibacterial compounds with novel modes of action.

April 1, 2008

Authors: Pathania R, Brown ED.
Reference: Biochem Cell Biol. 2008 Apr;86(2):111-5. doi: 10.1139/O08-011. Review.

Canadian Chemical Biology Network: biochemistry back to the future.

April 1, 2008

Authors: Brown ED, Thomas DY.
Reference: Biochem Cell Biol. 2008 Apr;86(2):ix, xi-xii. doi: 10.1139/o08-903.

Isolation of DNA aptamers for CDP-ribitol synthase, and characterization of their inhibitory and structural properties.

November 23, 2007

Authors: Allali-Hassani A, Pereira MP, Navani NK, Brown ED, Li Y.
Reference: Chembiochem. 2007 Nov 23;8(17):2052-7.

The Amino terminus of Bacillus subtilis TagB possesses separable localization and functional properties.

July 27, 2007

Authors: Bhavsar AP, D'Elia MA, Sahakian TD, Brown ED.
Reference: J Bacteriol. 2007 Oct;189(19):6816-23. Epub 2007 Jul 27.

Inhibitors of bacterial cystathionine beta-lyase: leads for new antimicrobial agents and probes of enzyme structure and function.

February 22, 2007

Authors: Ejim LJ, Blanchard JE, Koteva KP, Sumerfield R, Elowe NH, Chechetto JD, Brown ED, Junop MS, Wright GD.
Reference: J Med Chem. 2007 Feb 22;50(4):755-64.

Isolation of the rstA gene as a multicopy suppressor of YjeE, an essential ATPase of unknown function in Escherichia coli.

February 9, 2007

Authors: Campbell TL, Ederer CS, Allali-Hassani A, Brown ED.
Reference: J Bacteriol. 2007 Apr;189(8):3318-21. Epub 2007 Feb 9.

High-throughput screening for human lysosomal beta-N-Acetyl hexosaminidase inhibitors acting as pharmacological chaperones.

February 1, 2007

Authors: Tropak MB, Blanchard JE, Withers SG, Brown ED, Mahuran D.
Reference: Chem Biol. 2007 Feb;14(2):153-64.

A 2.13 A structure of E. coli dihydrofolate reductase bound to a novel competitive inhibitor reveals a new binding surface involving the M20 loop region.

November 30, 2006

Authors: Summerfield RL, Daigle DM, Mayer S, Mallik D, Hughes DW, Jackson SG, Sulek M, Organ MG, Brown ED, Junop MS.
Reference: J Med Chem. 2006 Nov 30;49(24):6977-86.

Lesions in teichoic acid biosynthesis in Staphylococcus aureus lead to a lethal gain of function in the otherwise dispensable pathway.

November 12, 2006

Authors: D'Elia MA, Pereira MP, Chung YS, Zhao W, Chau A, Kenney TJ, Sulavik MC, Black TA, Brown ED.
Reference: J Bacteriol. 2006 Jun;188(12):4183-9.

Wall teichoic acid polymers are dispensable for cell viability in Bacillus subtilis.

September 29, 2006

Authors: D'Elia MA, Millar KE, Beveridge TJ, Brown ED.
Reference: J Bacteriol. 2006 Dec;188(23):8313-6. Epub 2006 Sep 29.

The worm turns for antimicrobial discovery.

September 24, 2006

Authors: Bhavsar AP, Brown ED.
Reference: Nat Biotechnol. 2006 Sep;24(9):1098-100.

Cooperative and critical roles for both G domains in the GTPase activity and cellular function of ribosome-associated Escherichia coli EngA.

September 8, 2006

Authors: Bharat A, Jiang M, Sullivan SM, Maddock JR, Brown ED.
Reference: J Bacteriol. 2006 Nov;188(22):7992-6. Epub 2006 Sep 8.

Non-ribosomal factors in ribosome subunit assembly are emerging targets for new antibacterial drugs.

August 4, 2006

Authors: Comartin DJ, Brown ED.
Reference: Curr Opin Pharmacol. 2006 Oct;6(5):453-8. Epub 2006 Aug 4. Review.

The yjeQ gene is required for virulence of Staphylococcus aureus.

August 1, 2006

Authors: Campbell TL, Henderson J, Heinrichs DE,
Reference: Infect Immun. 2006 Aug;74(8):4918-21.

Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity.

July 20, 2006

Authors: Elowe NH, Nutiu R, Allali-Hassani A, Cechetto JD, Hughes DW, Li Y, Brown ED.
Reference: Angew Chem Int Ed Engl. 2006 Aug 25;45(34):5648-52. No abstract available.

Cell wall assembly in Bacillus subtilis: how spirals and spaces challenge paradigms.

June 1, 2006

Authors: Bhavsar AP, Brown ED.
Reference: Mol Microbiol. 2006 Jun;60(5):1077-90.

Microbiology: antibiotic stops 'ping-pong' match.

May 18, 2006

Authors: Brown ED.
Reference: Nature. 2006 May 18;441(7091):293-4.

Crystal structure of CTP:glycerol-3-phosphate cytidylyltransferase from Staphylococcus aureus: examination of structural basis for kinetic mechanism.

January 1, 2006

Authors: Fong DH, Yim VC, D'Elia MA, Brown ED, Berghuis AM.
Reference: Biochim Biophys Acta. 2006 Jan;1764(1):63-9. Epub 2005 Nov 10.

Conserved P-loop GTPases of unknown function in bacteria: an emerging and vital ensemble in bacterial physiology.

December 1, 2005

Authors: Brown ED.
Reference: Biochem Cell Biol. 2005 Dec;83(6):738-46. Review.

Experimental screening of dihydrofolate reductase yields a "test set" of 50,000 small molecules for a computational data-mining and docking competition.

September 16, 2005

Authors: Elowe NH, Blanchard JE, Cechetto JD, Brown ED.
Reference: J Biomol Screen. 2005 Oct;10(7):653-7. Epub 2005 Sep 16.

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